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KMID : 0043320100330050681
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Archives of Pharmacal Research
2010 Volume.33 No. 5 p.681 ~ p.689
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The Inhibitory Effect of Ginseng Pectin on L-929 Cell Migration
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Zhou Yifa
Fan Yuying
Cheng Hairong
Liu Dan
Zhang Xu
Wang Bo
Sun Lin
Tai Guihua
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Abstract
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We tested the effects of ginseng pectin prepared by enzymatic hydrolysis of ginseng polysaccharides on cell migration. Ginseng pectin impaired the migration of L-929 cells and reduced their migration speed by up to 50% of control in the presence or absence of serum, suggesting it worked on both serum-dependent and serum-independent migration pathways. Ginseng pectin impaired cell migration via decreased cell spreading. These findings represent a significant contribution towards understanding the bioactivities of ginseng polysaccharides and applying them to health food and medicine.
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KEYWORD
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Polysaccharide, Ginseng pectin, Cell migration, Scratching assay, Transwell assay, Cell spreading
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